Genetic evaluation of infertile men

Mitochondrial Genetic Variation in Iranian Infertile Men with Varicocele

Objective Several recent studies have shown that mitochondrial DNA mutations lead to major disabilities and premature death in carriers. More than 150 mutations in human mitochondrial DNA (mtDNA) genes have been associated with a wide spectrum of disorders. Varicocele, one of the causes of infertility in men wherein abnormal inflexion and distension of veins of the pampiniform plexus is observe...

Pnm-17: The Comparative Evaluation of Infertile Women and Men

I-2: Current Evaluation and Treatment of The Infertile Men

Background Fifty percent of infertility involves a male factor. The evaluation begins with a history, physical exam and semen analysis x 2. The history should include questions about exposure to gonad toxins. The differential diagnosis of no ejaculate includes; retrograde ejaculation, failure of ejaculation (rare), failure of emission and psychogenic. Evaluation of absence of the vas deferens w...

Mitochondrial Genetic Variation in Iranian Infertile Men with Varicocele

BACKGROUND Several recent studies have shown that mitochondrial DNA mutations lead to major disabilities and premature death in carriers. More than 150 mutations in human mitochondrial DNA (mtDNA) genes have been associated with a wide spectrum of disorders. Varicocele, one of the causes of infertility in men wherein abnormal inflexion and distension of veins of the pampiniform plexus is observ...

Evaluation of sperm proteins in infertile men: a proteomic approach.

In this study, the sperm protein profile was compared between fertile and infertile men using 2-dimensional gel electrophoresis, liquid chromatography mass spectrometer analysis, and matrix-assisted laser desorption ionization-time-of-flight-mass spectrometry. Four unique proteins, semenogelin II precursor, prolactin-induced protein, clusterin isoform 1, and prostate-specific antigen isoform 1 ...